Gulp, September 30th is the deadline day for so many commitments and past-me has punted a LOT of things to this day.   Gonna need a list!

Tofacent is an oral medication used to treat rheumatoid arthritis (RA). It belongs to a class of drugs called Janus kinase (JAK) inhibitors, which work by blocking specific enzymes involved in the inflammatory process of RA. Here's how tofacitinib can help in treating rheumatoid arthritis:   Mechanism of Action Tofacitinib inhibits the activity of Janus kinase enzymes (JAK1, JAK2, JAK3), which play a crucial role in the signaling pathways that lead to inflammation and immune responses. By blocking these enzymes, tofacitinib reduces the inflammatory process that causes joint damage and symptoms in RA. Benefits Reduction in Symptoms: Tofacitinib can significantly reduce joint pain, swelling, and stiffness, leading to improved physical function and quality of life. Slows Disease Progression: By reducing inflammation, tofacitinib can help slow down the progression of joint damage. Improved Mobility: Patients often experience better mobility and less fatigue, enabling them to carry out daily activities more effectively. Flexibility in Administration: Tofacitinib is available in oral form, providing an alternative to injectable therapies. Usage Tofacitinib is usually prescribed when other RA treatments, such as methotrexate or TNF inhibitors, have not been effective or are not suitable. It can be used alone or in combination with other non-biologic disease-modifying antirheumatic drugs (DMARDs). Common Side Effects Headache Diarrhea Upper respiratory tract infections High blood pressure Elevated liver enzymes Serious Side Effects Increased risk of serious infections (e.g., tuberculosis, fungal infections) Blood clots Gastrointestinal perforations Increased cholesterol levels Risk of certain cancers Monitoring and Precautions Regular monitoring is essential while taking tofacitinib. This includes blood tests to check for infections, liver function, and lipid levels. It's important to discuss any pre-existing conditions, current medications, and potential risks with your healthcare provider before starting tofacitinib. Conclusion Tofacitinib can be a valuable option for managing rheumatoid arthritis, especially for patients who have not responded well to other treatments. By reducing inflammation and slowing disease progression, it helps improve overall quality of life for many RA patients. Always consult with your healthcare provider to determine the best treatment plan tailored to your specific condition.   Visit: Tofacent 5 mg

Remember when hamster butts were all the rage?     Alligator bar is the better name and it shall be called so.     Are we still guessing animals? I guess a squirrel and its fluffy tail. 

Happy happy birthday, Sal! I hope Roxy and Bronze spoil you. Enjoy your day ❤️

I love those ideas for the 'cave', much agreement on no water features for reasons The damage done by this storm is horrific, I keep seeing images on the news that are so heartbreaking. I feel very fortunate all my loved ones are accounted for.

My neck continues to be jacked up, I have a massage scheduled today.  I finally hit a wall, went to bed at 7:30 last night and woke up at 5am. Almost feel like a human again.

Still alive. Dad is still here and I'm still sick. Thinking a lot about the fact that I used to do more. Was I less tired? Or just less kind to myself? I have some lingering worry that my decline is due to resting too much and not pushing myself. But maybe it would have happened anyway. 

That's a lot of work. Is your knee okay now?

Thank you Harriet ❤️

I hope your birthday is sweet and restful, and that there are things to be glad of. ❤️